Miofibroblastos

miofibroblastos función 1 miofibroblastos y fibroblastos 2 miofibroblastos y fibroblastos diferencias 3 miofibroblastos histología 4 Myofibroblasts usually stain for the intermediate filament vimentin, which is a general mesenchymal marker, α-smooth muscle actin (human gene = ACTA2), and for palladin, which is a cytoskeletal actin scaffold protein. 5 Canonical and non-canonical pathways implicated in fibroblast–myofibroblast differentiation. Three of the best described pathways involved in myofibroblast phenotypic acquisition are the TGF-β1/Smad; HA/CD44/EGFR; and Wnt/β-catenin pathways: (A) TGF-β1 is released from the LAP complex and binds to TGFβRII dimers, enabling association with and the activation of TGFβRI. 6 Myofibroblast 7 Fibroblasts and Myofibroblasts 8 The myofibroblast in wound healing and fibrosis 9 Toggle share options 10 The discovery of the myofibroblast has allowed definition of the cell responsible for wound contraction and for the development of fibrotic changes. 12